Operating over USB under ASIO and WDM – No. The ASIO and WDM Audio drivers connect to the first box that the PC detects on the USB bus.
Multiple Titan and Atlas units can be connected to a Pro Tools | HDX card, Pro Tools | HD Native PCIe card or Pro Tools | HD Native Thunderbolt unit, and they will to operate in sample sync in Pro Tools | HD software. These interface devices come with ASIO drivers that can be used with software other than Pro Tools | HD.
Multiple Titan and Atlas units fitted with MDIO-Dante modules will operate in sample sync when connected to a Dante system and synchronised correctly. Dante Virtual Soundcard or a Dante PCIe card both can be used as the host interface in system like this.